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Transient Histone Deacetylase Inhibition Induces Cellular Memory Of Gene Expression And 3D Genome Folding
By Nature
HDAC inhibition alters the epigenome and the transcriptome
To disrupt the chromatin state balance of mESCs, we pulsed them with TSA for 4 h (Fig. 1a). To minimize pleiotropic effects, we optimized treatment conditions so that histone hyperacetylation ...Read more
