TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages

Entertainment

Tgf-Β Builds A Dual Immune Barrier In Colorectal Cancer By Impairing T Cell Recruitment And Instructing Immunosuppressive Spp1+ Macrophages

By Nature

Cañellas-Socias, A., Sancho, E. & Batlle, E. Mechanisms of metastatic colorectal cancer. Nat. Rev. Gastroenterol. Hepatol. 21, 609–625 (2024). Le, D. T. et al. PD-1 blockade in tumors with mismatch-repair deficiency. N. Engl. J. Med. 372, 2509–2520 ( ...Read more